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        Established in 2018, Ruige Pharmaceutical?is committed to the fields of tumors, autoimmunity and metabolism, and develops "first-in-class" and "best-in-class" innovative drugs with independent intellectual property rights. Recently, Ruige Pharmaceutical?announced that its new generation of CDK2/4/6 small- molecule inhibitor RGT-419B has been received FDA approval for clinical research. RGT-419B is a new-generation tumor-targeted inhibitor with an optimized kinase activity spectrum. It is expected to improve the safety of currently approved CDK4/6 inhibitors and overcome resistance to these inhibitors. These inhibitors are used in combination with endocrine therapy to treat patients with premenopausal/postmenopausal hormone receptor positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) advanced or metastatic breast cancer. In cell model experiments, RGT-419B showed single-drug activity, which has a greater inhibitory effect on the growth of estrogen receptor positive (ER+) tumor cells. In ER+ breast cancer cells resistant to currently approved CDK4/6 inhibitors, RGT-419B showed complete inhibition of cancer cell proliferation. In these experiments, when RGT-419B is used in combination with a selective estrogen receptor degrader or PI3K signaling pathway inhibitor, its inhibitory effect on tumor cells is further enhanced. As a single agent and used in combination with other approved therapies, RGT-419B will initially be developed for the treatment of human epidermal growth factor receptor 2 negative (HER2-), ER+ breast cancer patients who have primary or acquired resistance to CDK4/6 inhibitors. With the widespread adoption of CDK4/6 inhibitors in clinical practice, patients with refractory and relapsed patients are becoming larger and clinically significant unmet medical needs. The clinical development project of RGT-419B will solve this resistance to CDK4/6 and other hormone receptor modulating therapies, and provide new opportunities for improving the survival and quality of life of patients with advanced breast cancer. RGT-419B is the first of many innovative oncology drugs being developed by Ruige Pharmaceutical. Founder and CEO Dr. Qiu Xiayang said: "This milestone marks the successful entry of Ruige Pharmaceutical into the field of tumor treatment. We have found the best choice for multiple CDKs through our self-developed AI-assisted new drug development CARD platform. Successfully promoted innovative drugs to enter the clinical development stage in the United States. At the same time, we are very excited that this opportunity can bring new and differentiated treatment options to many breast cancer patients around the world.
        此次大会全称为台湾国际半导体展(SEMICON Taiwan 2021)由国际半导体产业协会(SEMI)主办。
        本次活动截稿时间为2022年1月15日,稿件请投递至邮箱:wenqian.li@chinaipic.com,投递时请在邮件主题标明:学校+姓名+联系方式。 活动从即日起开始,欢迎大家踊跃报名参加!
        本次活动截稿时间为2022年1月12日,稿件请投递至邮箱:wenqian.li@chinaipic.com,投递时请在邮件主题标明:学校+姓名+联系方式。 活动从即日起开始,欢迎大家踊跃报名参加!
        Can artificial intelligence (AI) be registered as an inventor? As Stephen Thaler, the owner of Dabus, succeeded in letting AI be recognized as an inventor in South Africa and Australia, the challenge has transferred to Europe. In September, the UK court rejected the notion that the AI system Dabus is an inventor in its own right. However, after Thaler failed the appeal in the UK, the situation became a little different in Germany. The German Federal Patent Court gave a solution. The decision pointed a way forward in the debate surrounding how inventions created by AI can be correctly registered. The person behind the process must be named as the inventor on the inventor form, and this may be supplemented by the AI system. Patent authorities and courts around the globe have dealt with the inventions of Dabus. The German Federal Patent Court has now come to a pragmatic decision over DE1020191281202. According to the court, the listed inventor must be a natural person, even if the AI has identified both the problem and the solution. At the same time, however, the AI system itself can be additionally named. There is also a great deal of academic interest in the proceedings because of the fundamental role of AI in the invention protection. Following the decisions in Germany and the UK, the patent scene awaits the hearing at the European Patent Office on 21 December 2021. Reference: https://www.osborneclarke.com/insights/court-appeals-dabus-decision-highlights-debate-patents-ai-derived-inventions https://www.juve-patent.com/news-and-stories/cases/german-federal-patent-court-points-to-solution-for-dabus-inventions/ https://www.pinsentmasons.com/out-law/news/german-court-considers-ai-generated-inventions https://www.juve-patent.com/news-and-stories/cases/uk-court-of-appeal-opinion-diverges-on-dabus-and-patenting-ai/



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